Two precision medicine predictive tools for six malignant solid tumors: from gene-based research to clinical application

Abstract Background The current study aimed to construct competing endogenous RNA (ceRNA) regulation network and develop two precision medicine predictive tools for colorectal cancer (CRC).Methods Differentially expressed (DE) analyses were performed between CRC tissues and normal tissues.A ceRNA regulation network was constructed based on DElncRNA

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Short-Term Exercise Training Improves Insulin Sensitivity but Does Not Inhibit Inflammatory Pathways in Immune Cells from Insulin-Resistant Subjects

Background.Exercise has an anti-inflammatory effect against, and immune cells play critical roles in the development, of insulin resistance and atherosclerotic vascular disease (AVD).Thus, the goal of this study was to determine whether exercise improves insulin sensitivity in insulin-resistant subjects by downregulating proinflammatory Vest signal

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No short-cut in assessing trial quality: a case study

Abstract Background Assessing the quality of included trials is a central part of a systematic review.Many check-list type of instruments for doing this exist.Using a trial of antibiotic treatment for acute otitis media, Burke et al., BMJ, 1991, as the case study, this paper illustrates some limitations of the check-list approach to trial Wall Cloc

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